Immunogenomic profiling of circulating T cells in pediatric cancer patients during standard-of-care
Arash Nabbi, Yiyue Jiang, Osvaldo Espin‐Garcia, Suluxan Mohanraj, Stephanie Pedersen, Johanna Regala, Lauren M. Vernau, Jessica Perazzelli, David Maxwell Barrett, Trevor J. Pugh
The paper assesses T-cell dynamics in pediatric cancer patients during treatment, finding that immune checkpoint proteins and T-cell subsets change with therapy, and introduces a Dynamic Immunogenomic Score to predict relapse risk.
bioRxiv · Jan 10, 2025 · PreprintCancer Biology