Arash Nabbi

This study identifies factors regulating PD-L1 expression in Wilms tumor, showing chemotherapy, Wnt/β-catenin signaling, and mutations in CTNNB1 and DROSHA correlate with increased PD-L1 levels.

The paper assesses T-cell dynamics in pediatric cancer patients during treatment, finding that immune checkpoint proteins and T-cell subsets change with therapy, and introduces a Dynamic Immunogenomic Score to predict relapse risk.

The paper identifies four immune clusters in pediatric nervous system tumors using RNA-seq data and validates them with multiple methods, highlighting the need for personalized immunogenomic profiling.