Proof of concept of a novel ex vivo, in situ method for MRI and histological brain assessment
Josefina Maranzano, Mahsa Dadar, Antony Bertrand‐Grenier, Éve‐Marie Frigon, Johanne Pellerin, Sophie Plante, Simon Duchesne, Christine Lucas Tardif, Denis Boire, Gilles Bronchti
This paper demonstrates that perfusion-based in situ fixation of ex vivo brains preserves structural integrity and antigenicity, enabling accurate MRI and histological analysis up to 10 months post-mortem.
bioRxiv · Apr 8, 2020 · PreprintNeuroscience