Éve‐Marie Frigon

This study quantifies how formaldehyde fixation affects MRI metrics in postmortem human brains over time and provides a framework to correct for these effects.

This study compares the effects of three fixation solutions on neuronal quantification in mouse primary motor cortex, finding no significant differences between them.

This study examines how prolonged formalin fixation affects immunohistochemical and histochemical stains in postmortem human brains, finding decreased staining for specific markers over time.

The paper compares immunofluorescence quality in human brains fixed with different solutions and finds Sudan Black B effectively reduces autofluorescence.

The paper compares MRI-histology registration quality in human brain blocks fixed with different solutions and finds that SSS-fixed blocks require more landmarks for alignment but still achieve sufficient registration quality.

The paper compares T1- and T2-weighted MRI contrasts in brains fixed with different solutions, finding T2w images better suited for structural analysis.

This paper validates MRI brain volume measurements using ex vivo specimens and finds that SynthSeg provides accurate T1-weighted volumes compared to water displacement.

The paper examines how prolonged post-fixation affects immunohistochemical and histochemical staining in postmortem human brains, finding mixed correlations with staining intensity and limited effects of age and PMI.

The paper compares histological quality and antigenicity preservation in human brains fixed with different solutions, finding that AFS-fixed brains show better antigen labeling and tissue quality than NBF or SSS.

This study compares fixative solutions used in human gross anatomy labs to preserve brain tissue antigenicity in mice, finding that two solutions maintain sufficient antigenicity for immunohistochemistry.

This paper demonstrates that perfusion-based in situ fixation of ex vivo brains preserves structural integrity and antigenicity, enabling accurate MRI and histological analysis up to 10 months post-mortem.