Chemoproteomics-Enabled Ligand Screening Yields Covalent RNF114-Based Degraders that Mimic Natural Product Function
Mai Luo, Jessica N Spradlin, Scott M Brittain, Jeffery M McKenna, John A Tallarico, Markus Schirle, Thomas J Maimone, Daniel K Nomura
The paper identifies synthetic RNF114-based molecules that mimic natural product nimbolide's function in targeted protein degradation, demonstrating their utility in degrading BRD4 and BCR-ABL.
bioRxiv · Jul 12, 2020 · PreprintBiochemistry