Author

Scott M Brittain

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel K Nomura· 1 shared Jeffery M McKenna· 1 shared Jessica N Spradlin· 1 shared John A Tallarico· 1 shared Mai Luo· 1 shared Markus Schirle· 1 shared Thomas J Maimone· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Daniel K Nomura

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1 paper

Recent·Most cited

Chemoproteomics-Enabled Ligand Screening Yields Covalent RNF114-Based Degraders that Mimic Natural Product Function

Mai Luo, Jessica N Spradlin, Scott M Brittain, Jeffery M McKenna, John A Tallarico, Markus Schirle, Thomas J Maimone, Daniel K Nomura

The paper identifies synthetic RNF114-based molecules that mimic natural product nimbolide's function in targeted protein degradation, demonstrating their utility in degrading BRD4 and BCR-ABL.

bioRxiv · Jul 12, 2020 · PreprintBiochemistry