Autonomous and non-cell autonomous etiology of ciliopathy associated structural birth defects
Richard J. B. Francis, Jovenal T. San Agustin, Heather L. Szabo‐Rogers, Cheng Cui, Julie A. Jonassen, Thibaut Eguether, John A. Follit, Cecilia W. Y. Lo, Gregory J. Pazour
This study investigates the role of cilia in structural birth defects by analyzing Ift140 deficiency in mice, revealing both cell autonomous and non-cell autonomous mechanisms in craniofacial and heart development.
bioRxiv · Jun 7, 2023 · PreprintDevelopmental Biology