Gregory J. Pazour

This study shows that RhoA-ROCK-dependent actomyosin contractility drives extracellular vesicle release from the cilium in IMCD3 cells.

This study shows that Ift43 regulates Gli2 and Gli3 levels in cilia, affecting Hedgehog signaling and causing developmental defects in mice.

This study shows that Rag GTPases suppress renal cystic disease by inhibiting TFEB, independent of mTORC1, and identifies nuclear TFEB as a better biomarker than mTORC1 activation.

This study identifies sterol composition in primary cilia and shows its impact on Hedgehog signaling and membrane dynamics.

This study shows that Inpp5e is essential for maintaining photoreceptor outer segments, as its loss causes structural defects and cell loss in mice.

This study identifies IFT74 variants causing skeletal ciliopathy and motile cilia defects in humans and mice, revealing functional differences between motile and primary cilia.

This study investigates the role of cilia in structural birth defects by analyzing Ift140 deficiency in mice, revealing both cell autonomous and non-cell autonomous mechanisms in craniofacial and heart development.

This study shows that JNK signaling promotes cyst growth in ADPKD by enhancing cell proliferation and that inhibiting JNK reduces cyst severity.

WormCat is a web-based tool for annotating and visualizing gene set enrichment in C. elegans datasets, identifying both known and novel biological categories.

This study shows that IFT74 is essential for mouse spermatogenesis and male fertility by regulating axonemal microtubule assembly and fibrous sheath formation.