Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall, Andrew VonHandorf, Audrey Crowther, Omer A Donmez, Matthew R. Hass, Scott Richards, Carmy R. Forney, Hayley K Hesse, Sydney H Jones, Katelyn A Dunn, Jay Wright, Merrin Man‐Long Leong, , Matthew T. Weirauch
This study shows HCMV infection disrupts chromatin organization and reduces TEAD1 activity through multiple mechanisms, linking it to genetic risk loci for eye and ear development.
eLife · Sep 10, 2025Peer-reviewedGenomics