This study systematically investigates EBV transcriptional regulators' interactions with the human genome, identifying extensive gene expression alterations and chromatin changes.

Cell Genomics · Jul 15, 2026Peer-reviewedGenomics

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosis

Marissa Granitto, Ellie Kim, Carmy R. Forney, Cailing Yin, Arame A. Diouf, Andrew VonHandorf, Phillip J. Dexheimer, Sreeja Parameswaran, Xiaoting Chen, Omer A. Donmez, Hope Rowden, Casey O. Swoboda, Molly Shook, Katelyn A. Dunn, Hania Kébir, , Matthew T. Weirauch

This study shows that EBNA2 activity is increased in MS patients, altering gene expression and chromatin accessibility in EBV-transformed B cells.

medRxiv · Mar 9, 2026 · PreprintGenetic & Genomic Medicine

Comparison of PU.1 genomic binding across immune cells reveals cell type-specific roles in autoimmune disease

David A. Lewis, Molly Shook, Lucinda P. Lawson, Sreeja Parameswaran, Xiaoting Chen, Lee Edsall, Omer A. Donmez, Cailing Yin, Diego A. Rosado‐Tristani, Andrew VonHandorf, Phillip J. Dexheimer, Carmy R. Forney, Jennifer M. Felton, Arame A. Diouf, Katelyn A. Dunn, , Leah Claire Kottyan

medRxiv · Jan 27, 2026 · PreprintGenetic & Genomic Medicine

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall, Andrew VonHandorf, Audrey Crowther, Omer A Donmez, Matthew R. Hass, Scott Richards, Carmy R. Forney, Hayley K Hesse, Sydney H Jones, Katelyn A Dunn, Jay Wright, Merrin Man‐Long Leong, , Matthew T. Weirauch

This study shows HCMV infection disrupts chromatin organization and reduces TEAD1 activity through multiple mechanisms, linking it to genetic risk loci for eye and ear development.

eLife · Sep 10, 2025Peer-reviewedGenomics

Epigenetic and Transcriptional Dysregulation in CD4+ T cells of Patients with Atopic Dermatitis

Amy Eapen, Sreeja Parameswaran, Carmy R. Forney, Lee Edsall, Daniel Miller, Omer A. Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z. Magier, Mario Andres Pujato, Xiaoting Chen, Kenneth M. Kaufman, David I Bernstein, , Leah Claire Kottyan

This study identifies epigenetic and transcriptional dysregulation in CD4+ T cells of atopic dermatitis patients, linking genetic risk variants to altered chromatin accessibility and NFKB1 binding.

Journal of Allergy and Clinical Immunology · Feb 1, 2022Peer-reviewedGenomics

Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci

Ted Hong, Sreeja Parameswaran, Omer A. Donmez, Daniel Miller, Carmy R. Forney, Michael Lape, Mariana Saint Just Ribeiro, Jun Liang, Lee Edsall, Albert Frank Magnusen, William E. Miller, Iouri Chepelev, John B. Harley, Bo Zhao, Leah Claire Kottyan, Matthew T. Weirauch

This study shows EBNA2 alters chromatin structure and gene expression at autoimmune risk loci, linking viral infection to genetic risk mechanisms in autoimmune diseases.

Genome Research · Dec 1, 2021Peer-reviewedGenomics

Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies

Dinesh Manandhar, Lingyun Song, Ami M. Kabadi, Jennifer B. Kwon, Lee Edsall, Melanie Ehrlich, Koji Tsumagari, Charles A. Gersbach, Gregory E. Crawford, Raluca Gordân

The paper quantifies incomplete gene expression and chromatin accessibility changes during MyoD-induced transdifferentiation of human fibroblasts into myoblasts, linking chromatin remodeling deficiencies to incomplete reprogramming.

Nucleic Acids Research · Aug 28, 2017Peer-reviewedGenomics