Bo Zhao

A Human Genome-wide CRISPR-Cas9 Screen Reveals Host Factors That Support Epstein-Barr Virus B cell infection

This study uses a genome-wide CRISPR-Cas9 screen to identify host factors essential for EBV B cell infection, revealing new pathways and potential therapeutic targets.

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

This study shows HCMV infection disrupts chromatin organization and reduces TEAD1 activity through multiple mechanisms, linking it to genetic risk loci for eye and ear development.

PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial Biology

PASTA enhances spatial biology detection sensitivity while maintaining compatibility with multiple modalities and multiplexing strategies.

Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers

The paper introduces a method to identify differential super enhancers by considering internal dynamics, revealing novel structural alterations with distinct regulatory impacts and improving identification compared to existing methods.

Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci

This study shows EBNA2 alters chromatin structure and gene expression at autoimmune risk loci, linking viral infection to genetic risk mechanisms in autoimmune diseases.