Decoding sequence determinants of gene expression in diverse cellular and disease states
Avantika Lal, Alexander Karollus, Laura M. Gunsalus, David Garfield, Surag Nair, Alex M. Tseng, M. Grace Gordon, John Blischak, Bryce Van De Geijn, Tushar Bhangale, Jenna L. Collier, Nathaniel Diamant, Tommaso Biancalani, Héctor Corrada Bravo, Gabriele Scalia, Gökçen Eraslan
The paper introduces Decima, a model that predicts cell type- and condition-specific gene expression from DNA sequence using single-cell RNA sequencing data.
Nature Methods · May 25, 2026Peer-reviewedGenomics