Macrophage metabolism directs regenerative versus fibrotic healing through BMP signaling in the mouse digit tip
Mimi C. Sammarco, Siqi Liu, Ni Su, Madhumidha Ramesh, Charlotte Raymond, John Carleton, Anne Le, Alexander J. Trostle, Robert Tower, Jennifer Simkin
This study identifies a regeneration-specific macrophage population in mouse digit tip regeneration that uses BMP signaling and a unique metabolic profile to drive bone formation, absent in scar-forming injuries.
bioRxiv · May 7, 2026 · PreprintDevelopmental Biology