Anne Le

Chronic activation of a key exercise signal transducer, CaMKII, drives skeletal muscle aging and sarcopenia

This study shows chronic CaMKII activation drives skeletal muscle aging and sarcopenia, and partial inhibition in aged muscle improves function and shifts the transcriptome toward a youthful state.

Macrophage metabolism directs regenerative versus fibrotic healing through BMP signaling in the mouse digit tip

This study identifies a regeneration-specific macrophage population in mouse digit tip regeneration that uses BMP signaling and a unique metabolic profile to drive bone formation, absent in scar-forming injuries.

Immune-Mediated Necrotic Cell Death Initiated by Stressed Cardiomyocytes is a Major Contributor to Cardiomyocyte Loss Following Myocardial Infarction

This study shows that cytotoxic γδ-T cells contribute to cardiomyocyte death after myocardial infarction, and targeting STING and type I interferon pathways reduces infarct size.

Metabolic reprogramming by caloric restriction enhances acute phase virological control and reduces chronic inflammation in SIV-infected rhesus macaques

This study shows that caloric restriction in SIV-infected rhesus macaques reduces acute viremia, dampens inflammation, and improves metabolic function, but does not affect viral persistence.

Barth syndrome cellular models have dysregulated respiratory chain complex I and mitochondrial quality control due to abnormal cardiolipin

The paper identifies mitochondrial respiratory chain complex I and quality control dysregulation in TAZ-deficient cells and shows partial remediation via cardiolipin modulation.