Author

John Dronzek

Regeneron (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aris N. EconomidesiD· 2 shared Harikiran NistalaiD· 2 shared Shek Man ChimiD· 2 shared Adam E. LockeiD· 1 shared Alan R. ShuldineriD· 1 shared Alexander H. LiiD· 1 shared Anthony MarckettaiD· 1 shared Arunachalam VinayagamiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Aris N. EconomidesORCID

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2 papers

Recent·Most cited

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher V. Van Hout, Manuel A. R. Ferreira, Bin Ye, Alexander H. Li, Susannah D. Brydges, Arunachalam Vinayagam, Anthony Marcketta, Adam E. Locke, Jonas Bovijn, Niek Verweij, Tanima De, , Harikiran Nistala

The paper identifies SLC39A5 as a gene whose loss-of-function variants are associated with reduced type II diabetes risk and improved liver function in metabolic disorders.

eLife · Dec 13, 2024Peer-reviewedGenetic & Genomic Medicine

Functional modeling of NMIHBA-causing PRUNE1 variants reveals a requirement for its exopolyphosphatase activity.

Harikiran Nistala, John Dronzek, Claudia G. Gonzaga-Jauregui, Shek Man Chim, Saathyaki Rajamani, Samer J. Nuwayhid, Dennis Delgado, Elizabeth A. Burke, Ender Karaca, Matthew C. Franklin, Prasad S. Sarangapani, Michael S. Podgorski, Yajun Tang, Melissa G. Dominguez, Marjorie A. Withers, , Aris N. Economides

The paper investigates PRUNE1 variants causing NMIHBA, showing they disrupt exopolyphosphatase activity and lead to neurodevelopmental defects in mice.

bioRxiv · Mar 2, 2020 · PreprintGenetics