Author

Kristen Howell

Regeneron (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Katia P. Karalis· 2 shared Shek Man ChimiD· 2 shared Adam E. LockeiD· 1 shared Alan R. ShuldineriD· 1 shared Alexander H. LiiD· 1 shared Alexandros G. KokkosisiD· 1 shared Alice H. HuangiD· 1 shared Anthony MarckettaiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Katia P. Karalis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher V. Van Hout, Manuel A. R. Ferreira, Bin Ye, Alexander H. Li, Susannah D. Brydges, Arunachalam Vinayagam, Anthony Marcketta, Adam E. Locke, Jonas Bovijn, Niek Verweij, Tanima De, , Harikiran Nistala

The paper identifies SLC39A5 as a gene whose loss-of-function variants are associated with reduced type II diabetes risk and improved liver function in metabolic disorders.

eLife · Dec 13, 2024Peer-reviewedGenetic & Genomic Medicine

A Human Brain-Chip for modelling brain pathologies and screening of BBB crossing therapeutic strategies

Shek Man Chim, Kristen Howell, Alexandros G. Kokkosis, Brian Zambrowicz, Katia P. Karalis, Elias Pavlopoulos

The paper develops a human Brain-Chip model to study brain pathologies and test BBB-crossing therapies, showing in vitro/in vivo correlation for drug screening.

Pharmaceutics · Oct 10, 2024Peer-reviewedBioengineering

TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

Deepak A. Kaji, Kristen Howell, Zerina Balic, Dirk Hubmacher, Alice H. Huang

This study identifies TGFβ signaling as critical for neonatal tendon regeneration by promoting tenocyte recruitment and functional recovery.

eLife · Jun 5, 2020Peer-reviewedDevelopmental Biology