Heparinized Elastomeric Nanofibrillar Grafts: A Novel Approach for Mechanically Tunable, Cell-Supportive, and Thromboresistant Vascular Substitutes
Elizabeth C. Zermeno, John M. Kapitan, Alexander D Sandquist, Amanda Reke, Apurbo Kumar Paul, Jason MacTaggart, Stephen A. Morin, Kaspars Maleckis
This paper introduces heparin-functionalized elastomeric nanofibrillar grafts that meet three key requirements for vascular grafts: mechanical tuning, cell support, and thromboresistance, showing promising in vitro and pilot in vivo results.
bioRxiv · Jan 27, 2026 · PreprintBioengineering