Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Jeremiah A. Wala, Simona Dalin, Sophie Webster, Ofer Shapira, John P. Busanovich, Shahab Sarmashghi, Rameen Beroukhim, Pratiti Bandopadhayay, Verónica Rendo
This study shows that BRD4 gene deletions reduce toxicity from overexpression in ovarian and breast cancers, providing evidence for a novel mechanism in cancer progression.
Cell Genomics · Mar 19, 2025Peer-reviewedCancer Biology