Simona Dalin

The paper studies mutations and structural variants during double-strand break repair in budding yeast, finding that repair-associated deletions and template switches depend on microhomology and homeology.

This study shows that BRD4 gene deletions reduce toxicity from overexpression in ovarian and breast cancers, providing evidence for a novel mechanism in cancer progression.

This paper introduces two methods to detect recurrent genomic rearrangements in cancer genomes and identifies 80 simple and 29 complex rearrangements across 2,500 cancers.

The paper investigates mutation patterns during double-strand break repair in yeast, finding that deletions and tandem duplications occur with specific microhomology preferences and structural constraints.

The paper compares germline and somatic structural variants in cancer, identifying differences in their generating processes and selection, and develops a classifier to distinguish them in tumor samples without matched normals.