An activating mutation in Pdgfrb causes skeletal stem cell defects with osteopenia andovergrowth in mice
Hae Ryong Kwon, Jang Hwan Kim, John P. Woods, Lorin E. Olson
This study shows that a PDGFRβ mutation causes skeletal stem cell defects leading to osteopenia and overgrowth in mice by altering osteogenic and chondrogenic pathways.
bioRxiv · Jan 21, 2021 · PreprintDevelopmental Biology