Lorin E. Olson

This study identifies STAT5-IGF1 signaling as a pathway driven by constitutive PDGFRb activation that causes connective tissue overgrowth in mice, with implications for human disease.

This study identifies STAT1 as a suppressor of PDGFRβ-driven overgrowth in a mouse model of KOSAKI overgrowth syndrome.

This study shows that overactive PDGFRα and PDGFRβ signaling in mice leads to distinct but overlapping fibrotic and growth-related muscle changes, with sex-specific effects.

This study investigates the role of PDGFR-{beta} in uremic vascular calcification using ex vivo and in vivo models, showing that PDGFR-{beta} activation promotes calcification and VSMC phenotypic switching.

The paper investigates the role of Rac1 and SRF in cranial development, showing their necessity for maintaining mechanosensing mesenchyme in mice.

The paper traces adipocyte dedifferentiation into fibroblast-like cells at skin wounds using lineage tracing and identifies PDGF and TGFβ signaling as promoting this process.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

This study uses lineage tracing and single-cell transcriptomics to define cell populations and lineage relationships in the periodontal ligament.

This study shows that a PDGFRβ mutation causes skeletal stem cell defects leading to osteopenia and overgrowth in mice by altering osteogenic and chondrogenic pathways.

This study identifies the versican-hyaluronan complex as essential for vasculogenesis and primitive hematopoiesis by providing a niche for Flk1+ progenitors during gastrulation.