High- versus low-dose dietary n-3 PUFA treatment produces mixed effects on DNA methylation and epigenetic fidelity in breast adipose tissue
David Eugene Frankhouser, Hongwei Holly Yin, Martha Ann Belury, John W Newman, Lisa D. Yee
This study examines how high- and low-dose n-3 PUFA treatments affect DNA methylation and epigenetic fidelity in breast adipose tissue, finding dose-specific and directionally discordant changes in promoter methylation.
medRxiv · Mar 22, 2026 · PreprintGenetic & Genomic Medicine