David Eugene Frankhouser

Spatial Landscape of Pregnancy-Associated Triple Negative Breast Cancer and Mammary Gland Involution

This study compares transcriptional differences between pre- and post-involution PA-TNBC tissues using spatial transcriptomics, identifying distinct inflammatory and chromatin remodeling patterns in post-involution tumors.

Spatial context of cellular heterogeneity in triple-negative breast cancer reveals actionable subtypes

The paper identifies three TNBC subtypes based on spatial transcriptomics and cellular mapping, revealing distinct tumor microenvironment architectures and potential therapeutic targets.

Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics

The paper develops a pipeline for protein-level cell annotation in human PBMCs using mass spectrometry-based single-cell proteomics and validates it on unsorted samples.

Multiomic State-Transitions Reveal Post-Treatment Transcriptome Desynchronization in Acute Myeloid Leukemia

The paper uses a state-transition model to study transcriptome dynamics in AML, finding delayed miRNA responses and linking the Dlk1-Dio3 locus to treatment-induced desynchronization.

Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia

The paper shows that clinically relevant leukemia phenotypes emerge at the macrostate level from single cell data, revealing how disease states aggregate from noisy single cell transcriptomes.

High- versus low-dose dietary n-3 PUFA treatment produces mixed effects on DNA methylation and epigenetic fidelity in breast adipose tissue

This study examines how high- and low-dose n-3 PUFA treatments affect DNA methylation and epigenetic fidelity in breast adipose tissue, finding dose-specific and directionally discordant changes in promoter methylation.

Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancer

This study uses spatial transcriptomics to identify molecular and cellular differences between good and poor prognosis triple-negative breast cancer subtypes, revealing distinct gene signatures that could inform therapy.

Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia

This study develops a computational model of the AML bone marrow microenvironment and shows that combining TKIs with miR-126 inhibition can overcome treatment resistance by disrupting the protective vascular niche.

The Histone Chaperone CAF-1 Sustains Myeloid Lineage Identity

This study shows that CAF-1 maintains myeloid lineage identity by regulating chromatin accessibility and transcription factor control during differentiation.