PCSK9 Exhibits Novel Nuclear Localization in LSEC and Its Targeting with Bioinspired Nanoparticles Reduces Colorectal Liver Metastasis
Ander Martín, Maitane Duarte García-Escudero, HA Manzanilla García, Iratxe Bañares, Naroa Fontal, Jokin Eguia, Patricia García Gallastegui, Asier Vicente Benito, FRANCISCO JOSÉ SÁEZ, Olatz Crende, Alejandro Sánchez Barreiro, Joana Márquez, Abdel‐Majid Khatib, Iker Badiola
This study identifies novel nuclear localization of PCSK9 in liver sinusoidal endothelial cells and shows that targeting it with nanoparticles reduces colorectal liver metastasis.
bioRxiv · May 29, 2026 · PreprintCancer Biology