Heroin self-administration and extinction increases prelimbic cortical astroglia-synapse proximity and alters dendritic spine morphometrics that are reversed by N-acetylcysteine
Benjamin M. Siemsen, AR Denton, Kaylee N. Hooker, EA Carpenter, Meagan E. Prescot, AG Brock, MN Leath, Jon A. McFaddin, Jacqueline F. McGinty, Michael D. Scofield
This study shows heroin self-administration and extinction alter astrocyte structure and dendritic spine morphology in the prelimbic cortex, effects reversed by N-acetylcysteine.
bioRxiv · May 21, 2020 · PreprintNeuroscience