Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking
Adam R. Denton, Rachel E. Clarke, Lisa M. Green, Jayda Carroll-Deaton, Annaka M. Westphal, Benjamin M. Siemsen, Ashley G. Brock, Elizabeth A. Hochberg, Jacob Lavine, Makoto Taniguchi, Jacqueline F. McGinty, Alexander C.W. Smith, Constanza García‐Keller, James M. Otis, Michael D. Scofield
This paper identifies nitrergic interneurons as key mediators of cue-induced synaptic plasticity in D1 MSNs required for cocaine seeking, showing that targeting nNOS or mGluR5 blocks relapse.
bioRxiv · Apr 5, 2024 · PreprintNeuroscience