Stochasticity in Metabolism: Oxidative Stress Response Phenotypes As Emergent Consequences of Network Topology
Aleksandar Mihnev, Dana Luong, Jonah Porat, Roger Chang
The paper models oxidative stress response in E. coli using a genome-scale metabolic model to show that bimodal killing under H2O2 stress emerges from network topology and stochastic sampling.
bioRxiv · Oct 27, 2026 · PreprintSystems Biology