Author

Roger Chang

Albert Einstein College of MedicineORCID 0000-0001-5654-2480Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:differential expression· 1 Organism:E. coli· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aleksandar MihneviD· 1 shared Dana LuongiD· 1 shared Emanuel CunhaiD· 1 shared Gracelyn R. RichmondiD· 1 shared Jonah Porat· 1 shared Libusha KellyiD· 1 shared Óscar DiasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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1 shared paperSystems Biology

Aleksandar MihnevORCID

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2 papers

Recent·Most cited

Nutrient control enables metabolic reconstruction of L. rhamnosus GG and analysis of secretions

Gracelyn R. Richmond, Emanuel Cunha, Libusha Kelly, Óscar Dias, Roger Chang

The paper presents the first curated genome-scale metabolic model for L. rhamnosus GG, validated using multiple approaches and provides insights into its nutrient requirements and secretions.

mSystems · Oct 28, 2026Peer-reviewedSystems Biology

Stochasticity in Metabolism: Oxidative Stress Response Phenotypes As Emergent Consequences of Network Topology

Aleksandar Mihnev, Dana Luong, Jonah Porat, Roger Chang

The paper models oxidative stress response in E. coli using a genome-scale metabolic model to show that bimodal killing under H2O2 stress emerges from network topology and stochastic sampling.

bioRxiv · Oct 27, 2026 · PreprintSystems Biology