A stress response that allows highly mutated eukaryotic cells to survive and proliferate
Rebecca A. Zabinsky, Jonathan Mares, Richard She, Michelle K. Zeman, Thomas R. Silvers, Daniel F. Jarosz
The paper identifies a conserved stress response in yeast and human cancers that mitigates the cost of accumulated mutations, suggesting therapeutic targeting potential.
bioRxiv · Jan 9, 2019 · PreprintGenetics