Low-density Lipoprotein Receptor-related Protein 5 (LRP5)-deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature
John L. Ubels, Cassandra R. Diegel, Gabrielle E. Foxa, Nicole J. Ethen, Jonathan N. Lensing, Zachary Madaj, VARI Vivarium and Transgenics Core, Bart O. Williams
This study creates Lrp5-deficient rats using CRISPR/Cas9, showing reduced bone mass and abnormal retinal vasculature similar to human LRP5 deficiency.
The CRISPR Journal · Aug 1, 2020Peer-reviewedDevelopmental Biology