Bart O. Williams

Deletion of the Wnt regulator Znrf3 alters bone geometry without inducing high bone mass

This study shows that deleting Znrf3 in osteoblasts reduces trabecular bone mass and alters cortical bone structure, while Rnf43 deletion has minimal effects.

Frizzled 6 Drives EMT and Stromal Remodeling Downstream of SP1 in Basal-like Pancreatic Cancer

This study identifies FZD6 as a key driver of EMT and stromal remodeling in basal-like pancreatic cancer, downstream of SP1, with implications for therapeutic targeting.

Mutation of the Galectin-3 Glycan Binding Domain (Lgals3-R200S) Enhances Cortical Bone Expansion in Male and Trabecular Bone Mass in Female Mice

This study shows that the Lgals3-R200S mutation in mice reduces galectin-3 secretion and alters bone mass differently in males and females.

Dkk1 inhibition normalizes limb phenotypes in a mouse model of Fzd2 associated omodysplasia Robinow syndromes

This paper models a human FZD2 variant in mice, identifies limb and cleft palate phenotypes, and shows DKK1 inhibition can normalize limb defects.

Structure and Function of the Retina of Low-density Lipoprotein Receptor-related Protein 5 (Lrp5)-deficient Rats

This study creates a Lrp5 knockout rat model to study retinal vascular diseases, finding defects in retinal structure and function similar to human FEVR.

Low-density Lipoprotein Receptor-related Protein 5 (LRP5)-deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature

This study creates Lrp5-deficient rats using CRISPR/Cas9, showing reduced bone mass and abnormal retinal vasculature similar to human LRP5 deficiency.

An Osteocalcin-deficient mouse strain without endocrine abnormalities

This paper describes a new OCN-deficient mouse strain with no endocrine abnormalities, contrasting previous findings, and donates the strain for further study.