Olduvai domains downregulate mitochondrial pathways to promote human brain evolution and neoteny
Jonathon Keeney, David P. Astling, Vanessa Andries, Karl Vandepoele, Nathan Anderson, Jonathan M. Davis, Pamela Lopert, M I and Ansari Patel, Kenneth L Jones, Jonathan Vandenbussche, Kris Gevaert, An Staes, Santos J. Franco, Natasia Paukovich, Beat Vögeli, , James M. Sikela
This study shows Olduvai domains suppress mitochondrial pathways, delaying cellular maturation and promoting brain size increase in humans.
bioRxiv · Oct 21, 2024 · PreprintGenomics