Santos J. Franco

This study identifies Gsx2 as a regulator of oligodendrocyte precursor cell formation in zebrafish spinal cord through single-cell and single-nuclei multi-omics analyses.

The paper shows Notch signaling epigenetically primes neural progenitors to enhance Sonic Hedgehog signaling and promote oligodendrocyte differentiation in the developing mouse forebrain.

This study identifies meningeal-derived retinoic acid's role in suppressing Notch and Sox2 to regulate neurogenesis in neocortical progenitors.

This paper optimizes an in utero electroporation method to model DIPG in mice by expressing mutant oncogenes in neural progenitors, resulting in tumors with DIPG molecular features.

This study shows Olduvai domains suppress mitochondrial pathways, delaying cellular maturation and promoting brain size increase in humans.

This study uses in utero electroporation to induce mTOR pathway dysregulation in rodents, revealing early developmental abnormalities in neuronal migration and axon proliferation linked to malformations of cortical development.

The paper identifies a pre-OPC state and a gene regulatory network involving Ascl1 that drives oligodendrocyte fate specification in Shh-responsive neocortical progenitors.

The paper identifies Csmd2 as a novel interacting partner of Dab1, showing its role in Reelin-mediated dendrite and spine development in forebrain neurons.

The paper shows that loss of Shh signaling in dorsal progenitors leads to oligodendrocyte depletion, which recovers through differential contributions from dorsal and ventral lineages, with gray matter OPCs failing to recover.

The paper identifies an Lmx1a-driven Cux2 enhancer in the cortical hem, revealing its role in regulating Cux2 expression in neural progenitors during forebrain development.