Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated KDR/VEGFR2 receptors as modulators of anti-angiogenic therapies.
Rodrigo Almeida Toledo, Elena Garralda, Maria Mitsi, Tirso Pons, Jorge Monsech, Estela Vega, Álvaro Otero, Maria Isabel Albarran, Natalia Baños, Yolanda Durán, Victoria Bonilla, Francesca Sarno, Marta Camacho‐Artacho, Tania Sánchez‐Pérez, Sofia Hidalgo Perea, , Manuel M. Hidalgo
This study uses whole-exome sequencing of plasma cell-free DNA to analyze somatic mutations in metastatic colorectal cancer and identifies KDR/VEGFR2 mutations affecting anti-angiogenic therapy response.
bioRxiv · Aug 28, 2017 · PreprintGenomics