Author

Álvaro Otero

Research Institute Hospital 12 de OctubreORCID 0000-0002-7225-2835Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

María Velasco‐EsteveziD· 3 shared Miguel GallardoiD· 3 shared Joaquín Martínez‐LópeziD· 2 shared Manuel Pérez‐MartíneziD· 2 shared María Hernández‐SáncheziD· 2 shared Miguel Ángel Navarro-AguaderoiD· 2 shared Orlando Domı́ngueziD· 2 shared Osvaldo Graña‐CastroiD· 2 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersBiophysics

María Velasco‐EstevezORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Size Control of hnRNPK-based Nucleolar Condensates by RNA-Regulated Fusion Dynamics

Andrés R. Tejedor, Juan Luengo-Márquez, Pablo Burriel Llombart, Eduardo Pedraza, Álvaro Otero, María Velasco‐Estevez, Miguel Gallardo, Alberto Ocana, Rosana Collepardo‐Guevara, Jorge R. Espinosa

This study identifies how RNA-regulated fusion dynamics of hnRNPK-based nucleolar condensates prevent coalescence and maintain size control.

bioRxiv · Sep 17, 2026 · PreprintBiophysics

The mechanoreceptor PIEZO1 is a novel oncogene in glioma by promoting astrocyte reactivity

Pablo Blanco-Carlón, Miguel Ángel Navarro-Aguadero, Pedro Aguilar-Garrido, Álvaro Otero, María Hernández‐Sánchez, Andrés Arroyo-Barea, Osvaldo Graña‐Castro, Ricardo Gargini, Rosa García-Martín, Aurelio Hernández‐Laín, Manuel Pérez‐Martínez, Jesús Gómez Alonso, Sagrario Ortega, Joaquín Martínez‐López, Miguel Gallardo, María Velasco‐Estevez

This study identifies PIEZO1 as an oncogene in glioma that promotes astrocyte reactivity and is associated with worse prognosis in male patients.

bioRxiv · Apr 30, 2024 · PreprintCancer Biology

The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

Pedro Aguilar-Garrido, María Velasco‐Estevez, Miguel Ángel Navarro-Aguadero, María Hernández‐Sánchez, Prerna Malaney, Xiaroui Zhang, Marisa J.L. Aitken, Álvaro Otero, Marta Ibáñez-Navarro, Alejandra Ortiz-Ruiz, Diego Megı́as, Manuel Pérez‐Martínez, Gadea Mata, Jesús Gómez, Orlando Domı́nguez, , Miguel Gallardo

This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.

bioRxiv · Mar 7, 2023 · PreprintMolecular Biology

Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated KDR/VEGFR2 receptors as modulators of anti-angiogenic therapies.

Rodrigo Almeida Toledo, Elena Garralda, Maria Mitsi, Tirso Pons, Jorge Monsech, Estela Vega, Álvaro Otero, Maria Isabel Albarran, Natalia Baños, Yolanda Durán, Victoria Bonilla, Francesca Sarno, Marta Camacho‐Artacho, Tania Sánchez‐Pérez, Sofia Hidalgo Perea, , Manuel M. Hidalgo

This study uses whole-exome sequencing of plasma cell-free DNA to analyze somatic mutations in metastatic colorectal cancer and identifies KDR/VEGFR2 mutations affecting anti-angiogenic therapy response.

bioRxiv · Aug 28, 2017 · PreprintGenomics