Spatially organized developmental cell states link paraganglioma and neuroblastoma through chromaffin-neuroblast plasticity
Jiacheng Zhu, Wenyu Li, Valeriy Paramonov, Peng Cui, Valentin A. Poltorachenko, Jorrit Stada, Maria Arceo, Petra Bullova, Monika Plescher, Karolina Solhusløkk Höse, Per Kogner, Jakob J. E. Stenman, Catharina Larsson, Igor Adameyko, Michael Mints, , Susanne Schlisio
The paper identifies chromaffin-neuroblast plasticity as a mechanism linking paraganglioma and neuroblastoma through shared developmental states and hybrid cell populations.
bioRxiv · Aug 18, 2026 · PreprintCancer Biology