Jiacheng Zhu

Spatially organized developmental cell states link paraganglioma and neuroblastoma through chromaffin-neuroblast plasticity

The paper identifies chromaffin-neuroblast plasticity as a mechanism linking paraganglioma and neuroblastoma through shared developmental states and hybrid cell populations.

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

This paper shows that HIF2α reduces MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma, suggesting HIF2 has tumor suppressor rather than oncogenic function.

Comparative analysis of single cell lung atlas of bat, cat, tiger and pangolin

The paper compares single-cell transcriptomic data of lung tissues from bats, cats, tigers, and pangolins to analyze viral receptor distribution and immune responses to respiratory viruses.

Single cell chromatin accessibility of the developmental cephalochordate

This study creates the first single-cell chromatin accessibility atlas of the lancelet, revealing regulatory elements and developmental trajectories.

Single cell atlas of trisomy 21 cerebral cortex

This study creates the first single cell atlas of T21 cerebral cortex, identifying dysregulated genes and developing a platform for data exploration.

Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

This study creates the first single-cell brain atlas of domestic pigs, identifies cell types and their spatial distribution, and compares them with other species to reveal evolutionary and disease-related insights.