Sex-specific transcriptome similarity networks elucidate comorbidity relationships
Jon Sánchez-Valle, María Flores-Rodero, Felipe Xavier Costa, Jose Carbonell-Caballero, Iker Núñez-Carpintero, Rafael Tabarés-Seisdedos, Luis Mateus Rocha, Davide Cirillo, Alfonso Valencia
The paper identifies sex-specific transcriptomic similarities between comorbid diseases and finds that 13-16% of disease pairs show sex-specific transcriptome similarity, recapitulating 53-60% of known sex-specific comorbidities.
Communications Medicine · Dec 30, 2025Peer-reviewedBioinformatics