Luis Mateus Rocha

The paper develops an LLM-driven framework for drug repurposing in ER+ breast cancer, identifying 166 significant drug combinations using pathway analysis and consensus networks.

The paper identifies sex-specific transcriptomic similarities between comorbid diseases and finds that 13-16% of disease pairs show sex-specific transcriptome similarity, recapitulating 53-60% of known sex-specific comorbidities.

The paper analyzes experimentally-supported biomolecular networks to show they are ordered and far from the edge of chaos, with new measures and simulations revealing greater rigidity than previously thought.

The paper identifies the metric backbone as a subgraph of social contact networks that preserves shortest paths and community structure, revealing its role in epidemic transmission and network robustness.

The paper identifies a conserved genetic program in male germ cells across species, revealing 161 new spermatogenesis genes and three potential causes of human infertility.