Calmodulin mutation N54I causes autosomal dominant CPVT in mice
Daniel J. Blackwell, Nieves Gómez‐Hurtado, Kyungsoo Kim, Paxton A. Ritschel, Carlos Tellet Cabiya, Huan He, Jose R Pinto, Eric J. Delpire, Björn C. Knollmann
This paper shows that a single copy of the N54I calmodulin mutation in mice causes CPVT-like arrhythmias, demonstrating the functional dominance of mutant calmodulin.
bioRxiv · Sep 18, 2026 · PreprintPhysiology