PGT-A Mosaicism Reporting Lacks Clinical Predictive Value: Evidence from a Multisite, Double-Blinded Study with Independent Validation Across 15,315 Single-Embryo Transfers
P. Gill, Xin Tao, Yiping Zhan, Francesca Mulas, Christian Simon Ottolini, Ludovica Picchetta, Silvia Caroselli, D Babariya, Dagan Wells, Georgina Clark, Elena Fernandez Marcos, Carlos Marin Vallejo, Vaidehi Jobanputra, Marie M. Werner, Richard Scott, , Antonio Capalbo
This study shows that reporting mosaicism in PGT-A based on intermediate copy number (ICN) does not improve clinical outcomes in embryo selection.
medRxiv · Jun 23, 2025 · PreprintGenetic & Genomic Medicine