Christian Simon Ottolini

This paper models polygenic embryo screening (PES) in IVF patients and finds it leads to small relative risk reductions in most cases due to low live birth rates and limited embryo availability.

The paper investigates the association between maternal age and meiotic recombination failure with triploid/haploid conceptions in humans, identifying a maternal age effect and new types of genome-wide maternal isodiploidy.

This study shows that reporting mosaicism in PGT-A based on intermediate copy number (ICN) does not improve clinical outcomes in embryo selection.

This study analyzes aneuploidy in arrested IVF embryos and finds that meiotic and mitotic aneuploidies are strongly associated with developmental arrest.

The paper identifies tripolar mitosis as a mechanism causing aneuploidy in human embryos and links it to maternal PLK4 genetic variants.