Antonio Capalbo

This paper models polygenic embryo screening (PES) in IVF patients and finds it leads to small relative risk reductions in most cases due to low live birth rates and limited embryo availability.

The paper investigates the association between maternal age and meiotic recombination failure with triploid/haploid conceptions in humans, identifying a maternal age effect and new types of genome-wide maternal isodiploidy.

This study shows that reporting mosaicism in PGT-A based on intermediate copy number (ICN) does not improve clinical outcomes in embryo selection.

The paper develops a methodology for selecting IVF cases with oocyte maturation defects and preimplantation embryo lethality, using whole-exome sequencing and bioinformatics to identify causative genetic variants.

The paper identifies potentially harmful genetic variants in euploid miscarriage embryos and highlights specific genes linked to miscarriage risk.