Antigen receptor locus dynamics is orchestrated near the sol-gel phase transition to enforce stepwise VDJ gene rearrangement
Nimish Khanna, Yaojun Zhang, Joseph S. Lucas, Olga K. Dudko, Cornelis Murre
The paper tracks VH-DHJH motion in B-lymphocytes and finds that constrained local motion and proximity to the sol-gel phase transition enable stepwise VDJ gene rearrangement.
bioRxiv · Oct 12, 2018 · PreprintImmunology