Cornelis Murre

The paper investigates how transcription and loop extrusion create spatial confinements that regulate genomic encounters in the immunoglobulin heavy chain locus.

The paper shows HEB and TCR signaling work together to increase Id3, which is needed for fetal γδ T cells to mature into IL-17-producing cells.

This study identifies a CTCF-binding insulator element that regulates receptor editing and B-cell tolerance by controlling chromatin loop extrusion and Ig{lambda} development.

The paper describes helical coiled nucleosome chromosome architectures across the cell cycle, using cryo-EM data and computational modeling to show dynamic structural changes and replication processes.

This study shows that human neutrophils reposition inflammatory genes to a transcriptionally permissive compartment within hours of microbial exposure, enabling rapid transcriptional responses.

The paper tracks VH-DHJH motion in B-lymphocytes and finds that constrained local motion and proximity to the sol-gel phase transition enable stepwise VDJ gene rearrangement.

This study characterizes the genome topology of neutrophils, revealing super-contraction and chromatin reorganization during differentiation.