Molecular BiologyMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewed
Mechanistic Modeling Explains the Production Dynamics of Recombinant Adeno-Associated Virus with the Baculovirus Expression Vector System
Francesco Destro, John Joseph, Prasanna Srinivasan…·Richard D. Braatz
The paper develops a mechanistic model of rAAV production in BEVS, identifying Rep78 levels and transgene expression as key factors limiting yields.
22 citations