Author

Prasanna Srinivasan

Massachusetts Institute of TechnologyORCID 0000-0002-4951-5799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Anthony J. SinskeyiD· 2 shared Caleb I. Neufeld· 2 shared Francesco DestroiD· 2 shared Jacqueline M. WolfrumiD· 2 shared John JosephiD· 2 shared Paul W. BaroneiD· 2 shared Richard D. BraatziD· 2 shared Stacy L. SpringsiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

Anthony J. SinskeyORCID

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3 papers

Recent·Most cited

BioengineeringMolecular Therapy AdvancesPeer-reviewedMay 1, 2026

Continuous Production of Recombinant Adeno-Associated Virus in the Insect Cell/Baculovirus Expression Vector System

John Joseph, Francesco Destro, Arella Yuan…·Stacy L. Springs

This study develops a continuous production process for recombinant adeno-associated virus (rAAV) using the Sf9/BEVS system, achieving stable yields over 4 weeks.

DOI 10.1016/j.omta.2026.201744

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Molecular BiologyMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedJun 2, 2023

Mechanistic Modeling Explains the Production Dynamics of Recombinant Adeno-Associated Virus with the Baculovirus Expression Vector System

Francesco Destro, John Joseph, Prasanna Srinivasan…·Richard D. Braatz

The paper develops a mechanistic model of rAAV production in BEVS, identifying Rep78 levels and transgene expression as key factors limiting yields.

22 citations

statistical model

𝕏 PostBluesky

NeuroscienceAdvanced BiologyPeer-reviewedNov 10, 2021

An Autonomous Molecular Bioluminescent Reporter (AMBER) for voltage imaging in freely moving animals

Prasanna Srinivasan, Nicole M Griffin, Dhananjay Thakur…·Luke S. Theogarajan

The paper introduces AMBER, a genetically encoded bioluminescent voltage indicator that does not require exogenous substrate, enabling voltage imaging in freely moving animals.

16 citations

C. elegansexperimental assay

𝕏 PostBluesky