Childhood-onset asthma is characterized by airway epithelial hillock-to-squamous differentiation in early life
Elin T.G. Kersten, J. Patrick Pett, Kristiina Malmström, Yoojin Chun, Marnix R. Jonker, Anna Wilbrey-Clark, Kaylee B. Worlock, Maarten van den Berge, Roel C.H. Vermeulen, Judith M. Vonk, Neil James Sebire, Jouko Lohi, Wim Timens, Sarah Amalia Teichmann, Supinda Bunyavanich, , Gerard H. Koppelman
RNA sequencing in bronchial biopsies from wheezing infants and children < 2 years shows evidence for an airway epithelial hillock-to-squamous differentiation pathway that marks the development of asthma.
bioRxiv · Jul 31, 2023 · PreprintGenomics