Gerard H. Koppelman

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

UnBlender enables cell type deconvolution in respiratory bulk RNA-seq data and provides routine validation of deconvolution accuracy.

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

RNA sequencing in bronchial biopsies from wheezing infants and children < 2 years shows evidence for an airway epithelial hillock-to-squamous differentiation pathway that marks the development of asthma.

This study identifies ANXA1 as a susceptibility locus for persistent wheezing through a meta-analysis of GWAS data from UK birth cohorts.

The paper screens 1400 FDA-approved drugs in CF patient-derived intestinal organoids using a functional assay to identify potential repurposing for rare CF genotypes.

This study examines the RSV response in bronchial epithelial cells from asthma patients and healthy donors, finding impaired antiviral responses in goblet and multiciliated cells in asthma.

The paper identifies three nasal DNA methylation CpG sites that predict childhood allergic disease with high accuracy, validated across Dutch and US Hispanic children.

The paper investigates how IL-33-induced gene expression in Th2 cells depends on IL-1RL1 haplotype and asthma status, finding stronger effects in risk haplotype carriers and a correlation with pauci-granulocytic asthma.

The paper integrates DNA methylation and gene expression networks to improve prediction of functional gene-gene associations using eQTMs and a novel integration pipeline.

This study shows that infant RSV immunoprophylaxis with palivizumab alters nasal epithelial DNA methylation at age 6, affecting antiviral defense pathways but not asthma.