This study identifies a monocyte-macrophage-fibroblast axis in post-COVID-19 lung fibrosis using multi-omic profiling and shows its potential as a therapeutic target.

bioRxiv · Sep 14, 2026 · PreprintSystems Biology

Childhood-onset asthma is characterized by airway epithelial hillock-to-squamous differentiation in early life

Elin T.G. Kersten, J. Patrick Pett, Kristiina Malmström, Yoojin Chun, Marnix R. Jonker, Anna Wilbrey-Clark, Kaylee B. Worlock, Maarten van den Berge, Roel C.H. Vermeulen, Judith M. Vonk, Neil James Sebire, Jouko Lohi, Wim Timens, Sarah Amalia Teichmann, Supinda Bunyavanich, , Gerard H. Koppelman

RNA sequencing in bronchial biopsies from wheezing infants and children < 2 years shows evidence for an airway epithelial hillock-to-squamous differentiation pathway that marks the development of asthma.

bioRxiv · Jul 31, 2023 · PreprintGenomics

Mapping interindividual dynamics of innate immune response at single-cell resolution

Natsuhiko Kumasaka, Raghd Rostom, Ni Huang, Krzysztof Polański, Kerstin B. Meyer, Sharad R. Patel, Rachel Boyd, Céline Gomez, Sam N. Barnett, Nikolaos I. Panousis, Jeremy Schwartzentruber, Maya Ghoussaini, Paul Lyons, Fernando J. Calero‐Nieto, Berthold Göttgens, , Sarah Amalia Teichmann

The paper develops GASPACHO to identify dynamic eQTLs in antiviral responses using single-cell RNA-seq, uncovering thousands of eQTLs and linking them to disease risk loci.

Nature Genetics · Jun 1, 2023Peer-reviewedGenetics